111982-49-1 Usage
Uses
Used in Pharmaceutical Industry:
Cyclohexanone, 2-(2-fluorophenyl)-2-(methylamino)-, hydrochloride is used as a pharmaceutical agent for its potential role in the treatment of mood disorders. Its dual action as a selective serotonin and norepinephrine reuptake inhibitor makes it a candidate for conditions such as depression and anxiety, where modulation of these neurotransmitters is crucial for symptom management.
Used in Research and Development:
In the field of medicinal chemistry, Cyclohexanone, 2-(2-fluorophenyl)-2-(methylamino)-, hydrochloride serves as a subject of research and development. Scientists are exploring its structure-activity relationships and pharmacological profile to understand its potential as a therapeutic agent and to possibly develop new drugs for mental health disorders.
Used in Drug Discovery:
Cyclohexanone, 2-(2-fluorophenyl)-2-(methylamino)-, hydrochloride is utilized in drug discovery processes to identify novel therapeutic agents. Its unique chemical structure and pharmacological activity provide a foundation for the design and synthesis of new compounds that may offer improved efficacy and safety profiles for the treatment of mood disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 111982-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,9,8 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 111982-49:
(8*1)+(7*1)+(6*1)+(5*9)+(4*8)+(3*2)+(2*4)+(1*9)=121
121 % 10 = 1
So 111982-49-1 is a valid CAS Registry Number.
111982-49-1Relevant academic research and scientific papers
ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS
-
, (2021/07/02)
Provided herein are arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders.
Synthesis of 2-(2-fluorophenyl)-2-methylamino-cyclohexanone as a new ketamine derivative
Moghimi, Abolghasem,Rahmani, Siyavash,Zare, Reza,Sadeghzadeh, Morteza
, p. 2021 - 2028 (2014/07/07)
The main goal of this article is to the present research on the development of ketamine derivatives. The target molecule was a fluoroderivative of ketamine, for which a multistep synthesis has been reported. This novel ketamine derivative, 2-(2-fluorophenyl)-2-methylamino-cyclohexanone, has been called fluoroketamine by our research group. The starting fluorobenzonitrile was reacted with the appropriate Grignard reagent followed by the bromination reaction to obtain α-bromocyclopentyl-(2-fluorophenyl)-ketone. The reaction of the obtained ketone with methylamine at -40 °C then resulted in the formation of α-hydroxycyclopentyl-(2-flourophenyl)-N-methylamine. Finally, the five-memberd ring cyclopentanol was expanded to the cyclohexylketone by a thermal rearrangement reaction. The HCl salt of the target molecule, which is soluble in water, was obtained by the acidification of the free fluoroketamine with HCl. Preliminary animal tests on mice have shown that the resulting fluoroketamine has some advantages over ketamine in terms of the effective dose and the recovery time. Copyright
