111986-49-3

Upstream product

• 5843-48-1 2-Nitrobenzoyl isocyanate 
• 111986-63-1 4-(5-Bromo-pyrimidin-2-yloxy)-3-chloro-5-trifluoromethyl-phenylamine 
• 105653-16-5 4-Amino-2-chloro-6-trifluoromethyl-phenol 

Relevant academic research and scientific papers

Synthesis and antitumor activities of novel benzoylphenylurea derivatives

Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.