1119898-27-9Relevant articles and documents
Efficient copper-catalyzed coupling of 2-haloacetanilides with phosphine oxides and phosphites under mild conditions
Jiang, Deshou,Jiang, Qun,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
experimental part, p. 3473 - 3477 (2009/05/09)
We have developed a highly efficient method for the copper-catalyzed coupling of 2-haloacetanilides with phosphine oxides and phosphites in the presence of a catalytic amount of copper(I) iodide and N-methylpyrrolidine-2- carboxamide under mild conditions (45-55°C); the P-arylation products were synthesized in good to excellent yields in short times using 2-bromotrifluoroacetanilides and 2-iodotrifluoroacetanilides as the starting materials. This represents the lowest reaction temperatures for copper-catalyzed P-arylation thus far. Georg Thieme Verlag Stuttgart.