111991-09-4 Usage
Description
Nicosulfuron is a kind of herbicides belonging to the sulfonylurea family. It is a broad-spectrum herbicide that can controls many kinds of maize weeds including both annual weeds and perennial weed including Johnsongrass, quackgrass, foxtails, shattercane, panicums, barnyardgrass, sandbur, pigweed and morningglory. It is a systemic selective herbicide, being effective in killing plants near the maize. This selectivity is achieved through maize’s capability of metabolizing Nicosulfuron into harmless compound. Its mechanism of action is through inhibiting the enzyme acetolactate synthase (ALS) of the weeds, blocking the synthesis of amino acids such as valine and isoleucine, and finally inhibiting the protein synthesis and causing death of weeds.
References
http://www.agchemaccess.com/Nicosulfuron
http://pmep.cce.cornell.edu/profiles/extoxnet/metiram-propoxur/nicosulfuron-ext.html
Chemical Properties
Different sources of media describe the Chemical Properties of 111991-09-4 differently. You can refer to the following data:
1. White Solid
2. White crystalline solid or powder. Phenolic
odor.
Uses
Different sources of media describe the Uses of 111991-09-4 differently. You can refer to the following data:
1. Herbicide.
2. Post-emergence sulfonylurea herbicide
Definition
ChEBI: A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen.
Agricultural Uses
Herbicide: Used as a post-emergence herbicide to control a
variety of weeds on field corn and popcorn crops. Some
formulations may be U.S. EPA restricted Use Pesticides
(RUP). Approved for use in EU countries.
Trade name
ACCENT?; BASIS?; CELEBRITY?;
CHALLENGER?; DASUL?; DPX 79406? Herbicide
(with Rimsulfuron); DPX-V9636?; GHIBLI?; LAMA?;
MATRIX? Herbicide (with Rimsulfuron); MILAGRO?;
MISTRAL?; MOTIVEL?; NISSHIN?; SAMSON?;
STEADFAST? (nicosulfuron + rimsulfuron)
Potential Exposure
Nicosulfuron is a sulfonylurea postemergence
herbicide used to control a variety of weeds on
field corn and popcorn crops. Some formulations may be
registered as United States Restricted Use Pesticides (RUP)
Metabolic pathway
In the four systems investigated, the primary
degradation pathway is to yield pyridine sulfonamide
and 4,6-dimethoxy-2-aminopyrimidine. The plant and its
microsomal system include the hydroxylation pathway
at the 4-position of the pyrimidine ring, resulting in
hydrolysis products by the cleavage of the sulfonylurea
linkage. In mammals, contraction or rearrangement of
the sulfonylurea linkage for nicosulfuron and N-
demethylated nicosulfuron yields two unique products
which have the N-pyridyl-N-pyrimidyl urea moiety and
result in the uracil metabolite.
Shipping
UN3077 or UN3082 Environmentally hazardous
substances, liquid or solid, n.o.s., Hazard Class: 9; Labels:
9-Miscellaneous hazardous material, Technical Name
Required.
Incompatibilities
Slowly hydrolyzes in water, releasing
ammonia and forming acetate salts. Decomposed >165℃.
Waste Disposal
It is the responsibility of chemical
waste generators to determine the toxicity and physical
properties and of a discarded chemical and to properly identify
its classification and certification as a hazardous waste and to
determine the disposal method. United States Environmental
Protection Agency guidelines for the classification determination
are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult and follow all regional, national, state
and local hazardous waste laws to ensure complete and accurate
classification and disposal methods.
Check Digit Verification of cas no
The CAS Registry Mumber 111991-09-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,1,9,9 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 111991-09:
(8*1)+(7*1)+(6*1)+(5*9)+(4*9)+(3*1)+(2*0)+(1*9)=114
114 % 10 = 4
So 111991-09-4 is a valid CAS Registry Number.
InChI:InChI:1S/C15H18N6O6S/c1-21(2)13(22)9-6-5-7-16-12(9)28(24,25)20-15(23)19-14-17-10(26-3)8-11(18-14)27-4/h5-8H,1-4H3,(H2,17,18,19,20,23)
111991-09-4Relevant articles and documents
Method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide
-
, (2021/10/05)
The invention belongs to the technical field of nicosulfuron original medicine production, and particularly relates to a method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, wherein the method comprises the following steps: reacting tetramethoxypropane with ethyl cyanoacetate to generate 1-cyano-4-methoxy-1-ethoxycarbonyl-1,3-butadiene (cyanoene for short, the same below); reacting cyano alkene with hydrogen sulfide to generate ethyl 2-mercaptonicotinate (sulfydryl substance for short) in a closed-loop manner; reacting the sulfydryl substance with dimethylamine, and then carrying out oxychlorination reaction to obtain sulfonyl chloride; carrying out ammonolysis reaction on the sulfonyl chloride and ammonia gas to obtain sulfonamide; and reacting sulfonamide with solid light and pyrilamine to obtain the nicosulfuron. According to the method for closed-loop synthesis of nicosulfuron by using hydrogen sulfide, each reaction step is mild and controllable, process equipment is simple, the production cost is low, the product quality is good, three wastes are reduced, energy is saved, the production environment is improved, and the goal of carbon neutralization is favorably realized.
Preparation method of nicosulfuron crude drug
-
Paragraph 0020; 0024; 0026; 0030; 0031; 0035, (2020/03/23)
The preparation method, of the nicosulfuron crude drug comprises the following steps: synthesizing, isocyanate group sulfonyl - NNNN, N-dimethyl nicotinamide: triphosgene 2 - triethylamine and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials in, reaction to synthesize nicosulfuron-N, N-dimethylnicotinamide 0-80 °C and 2 - amino - 4444, 6-dimethoxypyrimidine as main raw materials to synthesize nicosulfuron-N, N-dimethylaminopyridine as a main, raw material, and high yield; of nicosulfuron. 2 - The method provided by the invention comprises the following steps, synthesizing 2 - 2 -isocyanuric acid group, sulfonyl - NNNNor N-dimethylaminopyrimidinil in 0-100 °C reaction to form a nicosulfuron prodrug. by reacting. 2 - The preparation method comprises the following. steps, synthesizing nicosulfuron-N, N-dimethyl nicotinamide.
Nicosulfuron crystalline hydrate as well as preparation method and application thereof
-
Paragraph 0050; 0051; 0064-0069, (2019/10/23)
The invention provides nicosulfuron crystalline hydrate as well as a preparation method and the application thereof and belongs to the field of organic synthesis. The invention provides the nicosulfuron crystalline hydrate which has a good crystal form, does not absorb moisture or damp in the air, is good in stability and easy in drying and later processing, in addition, the product is high in chemical purity, uniform in granularity distribution and good in dispersibility, a preparation processed later is good in stability, rapid in disintegration speed, high in bioactivity, remarkable in quality advantage, free of phenomena of material moisture absorption and sticking in the process of drying, crushing, packaging and downstream preparation processing in production workshops, beneficial toclean production and preparation material blending uniformity, and in addition has the advantages of being simple and easy in production process, high in yield, low in cost, and the like.