111998-14-2Relevant academic research and scientific papers
Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
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Page 10, (2010/02/05)
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, addiction to opiates, addiction to alcohol, addiction to tobacco products, addiction to nicotine, schizophrenia and related diseases, depression and related conditions, Alzheimer's disease, Parkinson's disease, irritable bowel syndrome, and colitis. The compounds competitively inhibit central nervous system acting nicotinic receptor agonists and act at the putative α3β2* and α4β2 neuronal nicotinic receptors in the central nervous system.
Inter- and Intramolecular hetero Diels-Alder Reactions, XXI - Intramolecular hetero Diels-Alder Reaction of Alkylidene-1,3-dicarbonyl Compounds. Experimental Evidence for an Asymmetric Transition State
Tietze, Lutz F.,Brumby, Thomas,Brand, Siegbert,Bratz, Matthias
, p. 499 - 506 (2007/10/02)
The intramolecular hetero Diels-Alder reaction of heterodienes 13 is described.The heterodienes, which are obtained in situ by Knoevenagel condensation of aldehydes 12a-e with dimethylbarbituric acid (2), yield the cycloadducts 14a-e/15a-e and the ene adducts 16a, c-e/17a, c-e.The ratio of 14/15 was determined by HPLC.The resulting data are interpreted as experimental evidence of an asymmetrical transition state of the Diels-Alder reaction.
