112002-80-9Relevant academic research and scientific papers
Synthesis and antitumor activities of novel benzoylphenylurea derivatives
Okada,Koyanagi,Yamada,Haga
, p. 2308 - 2315 (2007/10/02)
Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.
