112014-59-2Relevant academic research and scientific papers
Dioxirane Oxidation of 3-Arylideneflavanones: Diastereoselective Formation of trans,trans Spiroepoxides from the E Isomers
Nemes, Csaba,Levai, Albert,Patonay, Tamas,Toth, Gabor,Boros, Sandor,et al.
, p. 900 - 905 (1994)
Oxidation of the E isomers of the 3-arylideneflavanones 1 by dimethyldioxirane in acetone solution at ambient temperature led to spiroepoxides trans,trans-2 in high yields (>/= 70percent) and complete diastereoselectivity.Steric interaction with the axial
Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones
Kupcewicz, Bogumi?a,Balcerowska-Czerniak, Grazyna,Ma?ecka, Magdalena,Paneth, Piotr,Krajewska, Urszula,Rozalski, Marek
, p. 4102 - 4106 (2013/07/26)
The E,Z-isomers of 3-arylidene substituted flavanone, chromanone and 3-aryl substituted flavone derivatives were tested in vitro for their cytotoxic activity against three cancer cell lines (HL-60, NALM-6, WM-115) and normal cell line (HUVEC). It was observed that substitution at C3 position led to significant enhance in cytotoxicity. Isomeric configuration of 3-arylideneflavanones had an influence on the cytotoxic potential. Multiple regression analysis combined with variable selection by genetic algorithm was used to model relationships between molecular descriptors and the cytotoxic activity. The most accurate QSAR models were based on a combination between energy of LUMO, experimental value of log P and partial charge on carbonyl oxygen (δO2).
FLAVANOID PART 7 : A NOVEL PHOTOSYNTHESIS OF 3-α-HYDROXYBENZYLFLAVONES FROM 3-ARYLIDENEFLAVANONES
Dhande, V.P.,Thakwani (nee Joshi), Poonam,Marathe, K.G.
, p. 3015 - 3024 (2007/10/02)
E-3 Arylideneflavanones 4 on UV irradiation using quartzware undergo auto-oxidation to 3-aroylflavones 5.Photolysis using pyrex filter in the presence of iodoform furnishes 3-α-hydroxybenzylflavones indicating the intermediacy of the hydroperoxide 11 and form a new general method for the synthesis of these compounds not available by other routes.
