1120327-20-9Relevant academic research and scientific papers
The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes
Ul Islam, Rafique,Johnson, Myron M.,Mohammed, Raushaan,Hean, Justin,Arbuthnot, Patrick,De Koning, Charles B.,Van Otterlo, Willem A.L.
experimental part, p. 88 - 94 (2011/06/09)
A small library of cholesterol-piperazine conjugates were synthesized by the reaction of cholesteryl chloroformate with a set of substituted piperazines in dichloromethane at room temperature. The conjugates, all obtained in good to excellent yields, were synthesized to be key components of nucleic acid transfection lipoplexes.
Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives
Islam, Rafique Ul,Hean, Justin,van Otterlo, Willem A.L.,de Koning, Charles B.,Arbuthnot, Patrick
body text, p. 100 - 103 (2009/04/16)
To advance the use of cationic lipids for non-viral nucleic acid vector formulation, a panel of novel nitrogen heterocycle cholesteryl derivatives containing a biodegradable carbamate linker was synthesised. Optimally acting piperazine and cyclen compound
