112057-05-3Relevant academic research and scientific papers
Pharmacokineticts of Catechol Cephalosporins. The Effect of Incorporating Substituents into the Catechol Moiety on Pharmacokinetics in a Marmoset Model
Bird, T. G. C.,Arnould, J. C.,Bertrandie, A.,Jung, F. H.
, p. 2643 - 2651 (2007/10/02)
Two series of cephalosporins A and B have been synthesized, bearing at C-3' catechols substituted with various electron withdrawing groups (Y) and differing links (X), and were evaluated for their in vitro antibacterial activity and their pharmacokinetics
Synthesis of Some Novel Potent and Selective Catechol O-Methyltransferase Inhibitors
Baeckstroem, Reijo,Honkanen, Erkki,Pippuri, Aino,Kairisalo, Pekka,Pystynen, Jarmo,et al.
, p. 841 - 846 (2007/10/02)
A series of disubstituted catechol derivatives was synthesized and tested as potential COMT inhibitors.The most active compounds were more than 1000 times more potent (IC 50 = 3-6 nM) in vitro than the known COMT inhibitor, 3',4'-dihydroxy-2-methylpropiop
