112076-61-6 Usage
Description
Deoxycholic acid-d4 (DCA-d4) is intended for use as an internal standard for the quantification of DCA (Item Nos. 20756 | 18231) by GC- or LC-MS. DCA is a secondary bile acid that is formed via microbial transformation of cholic acid in the colon. It can be conjugated to glycine or taurine to produce glycodeoxycholic acid (GDCA; ) or taurodeoxycholic acid (TDCA; ), respectively, in hepatocytes. DCA (0.2% v/v) inhibits spore germination induced by taurocholic acid (TCA; ) in seven C. difficile strains, as well as inhibits growth and decreases the cytotoxicity of C. difficile culture supernatants to Vero cells when used at a concentration of 0.02% v/v. It inhibits ionizing radiation-induced p53-dependent transcription in a reporter assay using HCT116 cells when used at a concentration of 200 μM. Fecal and intestinal tissue levels of DCA are increased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet. Increased serum DCA levels have been found in patients with colorectal cancer.
Uses
Deoxycholic-2,2,4,4-d4 Acid (CAS# 112076-61-6) is a useful isotopically labeled research compound.
Check Digit Verification of cas no
The CAS Registry Mumber 112076-61-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,0,7 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 112076-61:
(8*1)+(7*1)+(6*2)+(5*0)+(4*7)+(3*6)+(2*6)+(1*1)=86
86 % 10 = 6
So 112076-61-6 is a valid CAS Registry Number.
