112080-24-7Relevant articles and documents
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4- dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
Kappe, C. Oliver
, p. 49 - 51 (2007/10/03)
A series of pharmacologically active, functionalized 4-aryl-3,4- dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4- dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.
SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-6-METHYL-2-THIOXO-5-PYRIMIDINECARBOXYLIC ACID ESTERS
Atwal, Karnail S.,O'Reilly, Brian C.,Gougoutas, Jack Z.,Malley, Mary F.
, p. 1189 - 1192 (2007/10/02)
Substituted 1,2,3,4-tetrahydro-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid esters are prepared in high overall yield from 2-methylene-3-oxobutanoic acid esters and 2-(4-methoxybenzyl)-2-thiopseudourea hydrochloride.