112080-33-8

Basic information

• Product Name: ethyl 4-{3-nitrophenyl}-6-methyl-2-oxo-1-(phenylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Synonyms: ethyl 4-{3-nitrophenyl}-6-methyl-2-oxo-1-(phenylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 112080-33-8
• Molecular Formula: C₂₁H₂₁N₃O₅
• Molecular Weight: 395.40854
• Mol File: 112080-33-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 4-{3-nitrophenyl}-6-methyl-2-oxo-1-(phenylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-{3-nitrophenyl}-6-methyl-2-oxo-1-(phenylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(112080-33-8)
• EPA Substance Registry System: ethyl 4-{3-nitrophenyl}-6-methyl-2-oxo-1-(phenylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate(112080-33-8)

Safety Data

• Hazardous Substances Data: 112080-33-8(Hazardous Substances Data)

Upstream product

• 39562-16-8 ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate 
• 123371-44-8 nifetepimine 
• 100-39-0 benzyl bromide 
• 1024-41-5 benzyl tosylate 
• 106720-60-9 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester 

Relevant articles and documents

Regioselective N1-alkylation of 3,4-dihydropyrimidine-2(1H)-ones: Screening of their biological activities against Ca2+-ATPase

A regioselective N1-alkylation of 3,4-dihydropyrimidin-2(1H)-ones using a very efficient mild base Cs2CO3 and alkyl halides at room temperature has been reported. The selectivity of this methodology is excellent and the yields of the alkylated products are very good. Furthermore inhibitory action of both the 3,4-dihydropyrimidin-2(1H)-ones and the N1-alkylated derivatives were tested on Ca2+-ATPase, which revealed that the parent compounds can act as Ca2+-ATPase inhibitors whereas the N1-alkylated derivatives are inefficient for this purpose.