112086-82-5Relevant academic research and scientific papers
3,4-Diacetylhexane-2,5-dione - An effective synthon for synthesis of substituted azulene heteroanalogs by cyclocondensation reactions
Olekhnovich,Boroshko,Tkachenko,Pozharskii,Tsupak,Zhdanov,Olekhnovick
, p. 1553 - 1560 (1998)
The one-pot method for the synthesis of 4,8-dialkoxy-6-aryl-1,3-dimethylcyclohepta[c]furanium perchlorates has been developed. The method is based on the cyclocondensation of 3,4-diacetylhexane-2,5-diones with aromatic aldehydes and trialkyl orthoformates under the action of a 16% perchloric acid solution in acetic anhydride. Under similar conditions, with hydrogen sulfide, cyclohepta[c]thiophenium perchlorates have been obtained, while cyclohepta[c]pyrrolium perchlorates have been prepared with arylamines, ammonium acetate, or aliphatic amine acetates. A heteroanalog of azulene, 4,8-diethoxy-1,3-dimethyl-2-azaazulene, has been obtained for the first time. Hydrolysis of aza- and thiaazulenium salts gives the corresponding cyclohepta[c]pyrrol-4-ones and cyclohepta[c]thiophen-4-ones.
Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: High-affinity ligands to the α2δ subunit of voltage gated calcium channels
Stearns, Brian A.,Anker, Naomi,Arruda, Jeannie M.,Campbell, Brian T.,Chen, Chixu,Cramer, Merryl,Hu, Tao,Jiang, Xiaohui,Park, Kenneth,Ren, Kun Kun,Sablad, Marciano,Santini, Angelina,Schaffhauser, Herve,Urban, Mark O.,Munoz, Benito
, p. 1295 - 1298 (2007/10/03)
A novel class of 6-aryl-6H-pyrrolo[3,4-d]pyridazine ligands for the α2δ subunit of voltage-gated calcium channels has been described. Substitutions in the aryl ring of the molecule were generally not tolerated, and resulted in diminished bindin
