112098-17-6Relevant academic research and scientific papers
Acetamidoarenediazonium Salts: Opportunities for Multiple Arene Functionalization
Schmidt, Bernd,Elizarov, Nelli,Riemer, Nastja,H?lter, Frank
, p. 5826 - 5841 (2015/09/15)
Unlike their ortho counterparts, meta- and para-acetamidoanilines can be converted into the corresponding acetamidoarenediazonium salts. These offer various opportunities for multiple Pd-catalyzed arene functionalization reactions, such as Matsuda-Heck-, Suzuki-Miyaura- or Fujiwara-Moritani couplings. Acetamidoarenediazonium salts, accessible from simple acetamidoanilines, are starting points for multiple Pd-catalyzed arene functionalization reactions.
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema
Inoue, Takayuki,Morita, Masataka,Tojo, Takashi,Yoshihara, Kousei,Nagashima, Akira,Moritomo, Ayako,Ohkubo, Mitsuru,Miyake, Hiroshi
, p. 1219 - 1233 (2013/03/28)
Vascular adhesion protein-1 (VAP-1), an amine oxidase that is also known as a semicarbazide-sensitive amine oxidase (SSAO), is present in particularly high levels in human plasma, and is considered a potential therapeutic target for various inflammatory diseases, including diabetes complications such as macular edema. In our VAP-1 inhibitor program, structural modifications following high-throughput screening (HTS) of our compound library resulted in the discovery that thiazole derivative 10, which includes a guanidine group, shows potent human VAP-1 inhibitory activity (IC50 of 230 nM; rat IC 50 of 14 nM). Moreover, compound 10 exhibited significant inhibitory effects on ocular permeability in STZ-induced diabetic rats.
Spectroscopic characterization by laser flash photolysis of electrophilic intermediates derived from 4-aminostilbenes. Stilbene "nitrenium" ions and quinone methide imines
Bose, Rohit,Ahmad, Abid R.,Dicks, Andrew P.,Novak, Michael,Kayser, Kelly J.,McClelland, Robert A.
, p. 1591 - 1599 (2007/10/03)
This paper reports the observation in water-acetonitrile solutions of two electrophiles derived from 4-amino- and 4-acetylaminostilbene carcinogens - the 'nitrenium' ion ArCH=CHC6H4-N+R and the quinone methide imine ArCHOH
Liquid Crystals for Non-linear Optics: Mesophases Formed by Push-Pull Stilbenes and Diacetylenes
Fouquey, Claudine,Lehn, Jean-Marie,Malthete, Jacques
, p. 1424 - 1426 (2007/10/02)
The push-pull stilbene and diacetylene derivatives (1f-h) and (2c-k) display nematic and smectic phases, which may be of special interest for their non-linear optical properties.
