1121-03-5

Basic information

• Product Name: 4-Hydroxy-2-butanesulfonic acid gamma-sultone
• Synonyms: 2,4-BUTANESULTONE;4-Hydroxy-2-butanesulfonic acid gamma-sultone;3-methyl-1,2-oxathiolane 2,2-dioxide;(R,S)-3-Methyl-[1,2]oxathiolane2,2-dioxide;1,2-oxathiolane,3-methyl-,2,2-dioxide;4-hydroxy-2-butanesulfonicacigamma-sultone;3-Methyl-1,2-oxathiolan-2,2-dioxid;4-Hydroxy-2-butanesulfonic acid γ-sultone
• CAS NO: 1121-03-5
• Molecular Formula: C₄H₈O₃S
• Molecular Weight: 136.17
• EINECS: 214-325-2
• Mol File: 1121-03-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: -14 °C
• Boiling Point: 150°C/12mmHg(lit.)
• Flash Point: 93°C(lit.)
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.00631mmHg at 25°C
• Refractive Index: 1.4540-1.4570
• Storage Temp.: 0-10°C
• CAS DataBase Reference: 4-Hydroxy-2-butanesulfonic acid gamma-sultone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2-butanesulfonic acid gamma-sultone(1121-03-5)
• EPA Substance Registry System: 4-Hydroxy-2-butanesulfonic acid gamma-sultone(1121-03-5)

Safety Data

• RIDADR: 2810
• RTECS: RP5480000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1121-03-5(Hazardous Substances Data)

Usage

Uses

2,4-Butanesultone is used in preparation of Me oxatiolane dioxide.

InChI:InChI=1/C4H8O3S/c1-4-2-3-7-8(4,5)6/h4H,2-3H2,1H3

Upstream product

• 598-32-3 2-hydroxy-3-butene 
• 1120-71-4 1,3-propanesultone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 109-69-3 n-Butyl chloride 
• 71-36-3 butan-1-ol 
• 74-83-9 methyl bromide 

Downstream Products

• 91760-70-2 5-methyl-2-(3-nitro-phenyl)-isothiazolidine 1,1-dioxide 

Relevant articles and documents

Synthesis method of 2, 4-butane sultone

The invention discloses a synthesis method of 2, 4-butane sultone, which comprises the following steps: 1, dissolving 1, 3-propane sultone in a first organic solvent under the protection of inert gas in the whole process, then adding sodium hydrogen in batches, and heating to 40-50 DEG C after the sodium hydrogen is added; 2, dropwise adding a methylation reagent, and carrying out heat preservation reaction after dropwise adding; and 3, cooling to room temperature, adding ice water and a second organic solvent for extraction, and carrying out negative pressure rectification on the second organic solvent layer to obtain the final product 2, 4-butane sultone. The synthesis method has the advantages of low raw material cost, simple operation steps, mild reaction conditions, few reaction steps, easiness in purification and the like.

Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABA(B) receptor affinities

A series of γ-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABA(B) receptor investigated.

SYNTHESIS OF γ- AND δ-SULTONES FROM THE PRODUCTS OF CHLOROSULFONATION OF 1-CHLOROBUTANE

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