1121053-29-9Relevant academic research and scientific papers
Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
Shotwell, J. Brad,Baskaran, Subramanian,Chong, Pek,Creech, Katrina L.,Crosby, Renae M.,Dickson, Hamilton,Fang, Jing,Garrido, Dulce,Mathis, Amanda,Maung, Jack,Parks, Derek J.,Pouliot, Jeffrey J.,Price, Daniel J.,Rai, Roopa,Seal, John W.,Schmitz, Uli,Tai, Vincent W. F.,Thomson, Michael,Xie, Mi,Xiong, Zhiping Z.,Peat, Andrew J.
scheme or table, p. 565 - 569 (2012/09/11)
A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC50 10 nM), direct binding to purified NS4B protein (ICsub
CERTAIN NITROGEN CONTAINING BICYCLIC CHEMICAL ENTITIES FOR TREATING VIRAL INFECTIONS
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Page/Page column 277, (2009/04/25)
Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
