112122-40-4Relevant academic research and scientific papers
Catalytic Asymmetric Nucleophilic Addition of 3-Vinyl Indoles to Imines
Xue, Jia-Hui,Shi, Ming,Yu, Feng,Li, Xiao-Yun,Ren, Wen,Fu, Li-Na,Guo, Qi-Xiang
, p. 3874 - 3877 (2016)
The 3-vinyl indole is used as a nucleophile to react with aromatic and aliphatic imines. Chiral 3-substituted indoles bearing multiple functional groups are produced with up to 99% yield, a 98:2 E/Z ratio, and 97% ee. A possible mechanism is proposed to explain the observed stereoselectivities. This strategy provides an efficient way for the preparation of novel chiral 3-substituted indoles.
Synthesis of vinylindoles and vinylpyrroles by the Peterson olefination or by use of the Nysted reagent
Noland, Wayland E.,Etienne, Christopher L.,Lanzatella, Nicholas P.
experimental part, p. 381 - 388 (2011/05/14)
Vinylindoles and vinylpyrroles were prepared from their corresponding aldehydes or ketones using the Peterson olefination, or by use of the Nysted reagent, a commercially available gem-dimetallic compound. The two methods provide efficient and convenient
