112139-13-6 Usage
Core structure
The core of the molecule is a pyrimidine-2,4(1H,3H)-dione, which is a type of heterocyclic compound with a six-membered ring containing four carbon atoms and two nitrogen atoms.
Ribo-hexofuranuronosyl group attachment
The pyrimidine-2,4(1H,3H)-dione core is attached to a ribo-hexofuranuronosyl group, which is a sugar derivative commonly found in nucleic acids and other biological molecules.
Amino acid derivative
The ribo-hexofuranuronosyl group is further attached to an amino acid derivative, specifically a (2S)-2-aminononanoyl group, which is a non-proteinogenic amino acid.
Stereochemistry
The molecule has a specific stereochemistry at the 2S position of the aminononanoyl group, indicating that the amino group is on the second carbon and has an S configuration.
Biological processes
The molecule is involved in various biological processes, such as nucleic acid metabolism and energy production.
Pharmaceutical applications
It is a key component of certain drugs used to treat viral infections and autoimmune diseases, highlighting its importance in the fields of biochemistry and pharmacology.
Research interest
Due to its intricate structure and biological relevance, the chemical has garnered significant interest from researchers in the fields of biochemistry and pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 112139-13-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,3 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 112139-13:
(8*1)+(7*1)+(6*2)+(5*1)+(4*3)+(3*9)+(2*1)+(1*3)=76
76 % 10 = 6
So 112139-13-6 is a valid CAS Registry Number.
112139-13-6Relevant articles and documents
Synthesis and anticandidal properties of polyoxin L analogues containing α-amino fatty acids
Khare,Becker,Naider
, p. 650 - 656 (2007/10/02)
Analogues of polyoxin L containing amino acids with saturated fatty acid like side chains were synthesized from the benzyloxycarbonyl-protected α-amino fatty acid p-nitrophenyl ester and uracil polyoxin C. Transfer hydrogenolysis using palladium black and formic acid gave diastereomeric, dipeptidyl polyoxin L analogues containing α-aminooctanoic acid (3), α-aminododecanoic acid (4), or α-aminohexadecanoic acid (5) as the amine terminal residue in 40-60% yield. Diastereomers of 3 and 5 were resolved by using high-performance liquid chromatography on a reversed-phase column and designated as 3a, 3b and 5a, 5b. Analogues 3-5 were excellent inhibitors of chitin synthetase from Candida albicans; 4, the best inhibitor, had an ID50 of 0.5 μM. The L,L diastereomers of 3 and 5 were 1-2 orders of magnitude more potent chitin synthetase inhibitors than their D,L homologues. None of the synthetic polyoxin L analogues inhibited transport of trimethionine, but 3a, 4, and 5b caused decreases of 71%, 87%, and 83%, respectively, in the initial rate of uptake of dileucine. Compounds 3-5 were significantly more stable to peptidase degradation than polyoxin L analogues containing naturally occurring α-amino acids. Compound 4 inhibited growth of C. albicans in culture at 40-80 μg/mL. All other analogues were less potent antifungals. The results suggest that synthetic polyoxins can be designed to have increased affinity for a peptide transport system and to have increased stability against intracellular degradation in C. albicans.
