112159-27-0Relevant academic research and scientific papers
Amino Acids and Peptides; 59. Synthesis of Biologically Active Cyclopeptides; 9. Synthesis of 16 Isomers of Dolastatin 3; I. Synthesis of the 2-(1-aminoalkyl)-thiazole-4-carboxylic Acids
Schmidt, Ulrich,Utz, Roland,Lieberknecht, Albrecht,Griesser, Helmut,Potzolli, Bernd,et al.
, p. 233 - 236 (1987)
The synthesis of the optically active Dolastatin 3 building block 2-(1-amino-3-cyanopropyl)-thiazole-4-carboxylic acid is described as a prerequisite for the total synthesis of dolastatin isomers.
Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis
Jacobsen, Christian Borch,Nielsen, Daniel Steen,Meldal, Morten,Diness, Frederik
, p. 6940 - 6945 (2019/06/10)
Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hete
Polythiazole linkers as functional rigid connectors: A new RGD cyclopeptide with enhanced integrin selectivity
Ruiz-Rodriguez,Miguel,Preciado,Acosta,Adan,Bidon-Chanal,Luque,Mitjans,Lavilla,Albericio
, p. 3929 - 3935 (2014/11/27)
Polythiazole amino acids clasp linear peptides to generate cyclic derivatives, however, the resulting species are not merely stapled peptides but bear a complex heterocyclic moiety displaying its intrinsic set of interactions. As a proof of concept, a bisthiazole moiety has been grafted onto an RGD sequence to deliver a new cilengitide analogue with improved integrin selectivity and remarkable in vivo antiangiogenic activity.
SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS
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Page/Page column 17, (2008/06/13)
Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of For
Total synthesis of nosiheptide. Synthesis of thiazole fragments
Koerber-Ple,Massiot
, p. 1309 - 1315 (2007/10/03)
The preparation of three new thiazole derivatives from natural products is described, as well as improvements in the synthesis of ethyl 2-aminomethyl-4-thiazolecarboxylate.
