112162-23-9

Upstream product

• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 1152-61-0 N-Cbz-L-Asp 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 94664-82-1 (3S)-3-benzyloxycarbonylamino-4-hydroxybutanoic acid 

Downstream Products

• 574005-82-6 3-benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-butyric acid benzyl ester 
• 98833-27-3 (3S,4S)-1-(tert-butyldimethylsilyl)-3-benzyloxycarbonylamino-4-(tert-butyldimethylsilyloxymethyl)azetidin-2-one 
• 112162-25-1 (S)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-(4-methoxy-benzyl)-azetidin-2-one 
• 574005-84-8 (2R,3R)-3-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-2-iodo-butyric acid benzyl ester 

Relevant academic research and scientific papers

A new entry to polyfunctionalized 4,5-trans disubstituted oxazolidin-2-ones from L-aspartic acid

A straightforward synthesis of enantiomerically pure (4R,5S)-5-oxazolidinecarboxylic acid, 2-oxo-4-[(t-butyldimethyl-silyloxy)methyl]-, benzyl ester and of (4S,5S)-4-oxazolidinecarboxylic acid, 2-oxo-5-[(t-butyldimethylsilyloxy)methyl]-, benzyl ester was envisaged starting from readily available L-aspartic acid. The key step is the diastereoselective addition of iodine with the introduction of a new stereogenic centre.