1121640-33-2Relevant academic research and scientific papers
Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Tecle, Haile,Shao, Jianxing,Li, Yanhong,Kothe, Michael,Kazmirski, Steven,Penzotti, Julie,Ding, Yuan-Hua,Ohren, Jeffrey,Moshinsky, Deb,Coli, Rocco,Jhawar, Nidhi,Bora, Emilia,Jacques-O'Hagan, Suzanne,Wu, Joe
scheme or table, p. 226 - 229 (2009/05/26)
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket
