112167-99-4

Upstream product

• 116822-46-9 C₃₄H₄₈O₅Si 
• 49826-05-3 (R)-(+)-methyl 2-oxo-1-cyclopentaneacetate 
• 112167-98-3 C₁₈H₃₀O₅ 
• 116822-51-6 4-((2R,3R,6R)-2,3-Dimethyl-1,4-dioxa-spiro[4.4]non-6-yl)-3-oxo-butyric acid methyl ester 
• 112167-95-0 ((2R,3R,6R)-2,3-Dimethyl-1,4-dioxa-spiro[4.4]non-6-yl)-acetic acid methyl ester 
• 112167-97-2 C₁₄H₂₂O₅ 
• 112167-96-1 C₁₄H₂₀O₅ 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 95730-88-4 (3aR,4S,5R,6aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(tetrahydro-pyran-2-yloxy)-hexahydro-pentalen-1-one 

Relevant academic research and scientific papers

CHIRAL SYNTHESIS OF ISOCARBACYCLIN -9-METHANO-Δ6-PGI1> INTERMEDIATE VIA RHODIUM-CATALYZED INTRAMOLECULAR C-H INSERTION REACTION

A key intermediate for the synthesis of isocarbacyclin, a promising therapeutic agent for cardiovascular and circulatory disorders, has been synthesized from (R)-(+)-methyl 2-oxo-1-cyclopentaneacetate by employing rhodium(II)-catalyzed intramolecular C-H insertion reaction of α-diazo β-keto ester as a key step.