1121703-17-0

Basic information

• Product Name: C₂₂H₂₆N₂O₆
• Synonyms: C₂₂H₂₆N₂O₆
• CAS NO: 1121703-17-0
• Molecular Weight: 414.458
• Mol File: 1121703-17-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆N₂O₆(1121703-17-0)
• EPA Substance Registry System: C₂₂H₂₆N₂O₆(1121703-17-0)

Safety Data

• Hazardous Substances Data: 1121703-17-0(Hazardous Substances Data)

Upstream product

• 205748-62-5 (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide 
• 1084-74-8 3-(2,5-dimethoxybenzoyl)propionic acid 

Downstream Products

• 1121703-35-2 C₂₂H₂₄N₂O₆ 

Relevant articles and documents

Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors

The involvement of μ-calpain in neurological disorders, such as stroke and Alzheimer's disease has attracted considerable interest in the use of calpain inhibitors as therapeutic agents. 4-Aryl-4-oxobutanoic acid amide derivatives 4 were designed as acyclic variants of μ-calpain inhibitory chromone and quinolinone derivatives. Of the compounds synthesized, 4c-2, which possesses a 2-methoxymethoxy group at the phenyl ring and a primary amide at the warhead region most potently inhibited μ-calpain (IC50 = 0.34 μM). Our findings suggest that the 4-aryl-4-oxobutanoic acid amide derivatives should be considered as a new family of μ-calpain inhibitors.