112181-70-1

Upstream product

• 68236-23-7 2-chloro-6,7-dimethoxy-3-quinolinecarboxaldehyde 
• 18527-19-0 4-chlorophenylthioacetonitrile 

Downstream Products

• 112181-66-5 3-(4-Chloro-phenylsulfanyl)-7,8-dimethoxy-2-(4-methyl-piperazin-1-yl)-benzo[b][1,8]naphthyridine 
• 112181-65-4 3-(4-Chloro-phenylsulfanyl)-7,8-dimethoxy-2-morpholin-4-yl-benzo[b][1,8]naphthyridine 
• 112181-64-3 3-(4-Chloro-phenylsulfanyl)-7,8-dimethoxy-2-piperidin-1-yl-benzo[b][1,8]naphthyridine 

Relevant academic research and scientific papers

A Convenient Synthesis of 2,3-Disubstituted Benzonaphthyridines; A Novel Annelation Reaction of 2,3-Disubstituted Quinolines

2-Chloro-3-(2-substituted 2-cyanovinyl)quinolines undergo cyclization on reaction with an excess of a secondary amine to give 3-substituted 2-aminobenzonaphthyridines in moderate to high yields.