1121970-20-4Relevant academic research and scientific papers
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists
Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Xiao, Wei,Peterson, Matthew L.,Nasser, Nadia,Maher, Michael P.,Ao, Hong,Bhattacharya, Anindya,Kansagara, Mena,Scott, Brian P.,Luo, Lin,Rynberg, Raymond,Rizzolio, Michele,Chaplan, Sandra R.,Wickenden, Alan D.,Guy Breitenbucher
scheme or table, p. 40 - 46 (2009/04/10)
We have identified and synthesized a series of 2,7-diamino-thiazolo[5,4-d]pyrimidines as TRPV1 antagonists. An exploration of the structure-activity relationships at the 2-, 5-, and 7-positions of the thiazolo[5,4-d]pyrimidine led to the identification of
