1122-40-3Relevant academic research and scientific papers
Kepner-Tregoe decision analysis as a tool to aid route selection. Part 2. Application to AZD7545, a PDK inhibitor
Moseley, Jonathan D.,Brown, David,Firkin, Catherine R.,Jenkin, Shelley L.,Patel, Bharti,Snape, Evan W.
, p. 1044 - 1059 (2013/01/03)
Kepner-Tregoe decision analysis was formally used as an aid to route selection, as outlined in the preceding paper. Over 40 paper routes were assessed for suitability for both immediate and longer term manufacture of AZD7545, a compound in the early stages of development. Eight routes were then investigated in full in the laboratory, and a further four in part, over a period of 3-4 months. From this exercise, the preferred long-term manufacturing route was identified before the first pilot scale manufacture had been completed. This route selection exercise worked well in this case where a large number of potential routes had to be considered using limited resources. It was also an effective means of bringing some long-term manufacturing issues to the fore at an early stage in development.
Substituted-4-alkylthioalkane-sulfonanilides and operatives
-
, (2008/06/13)
Alkane- and monohaloalkane-sulfonanilides substituted in the para position by alkylthio, alkylsulfinyl and alkylsulfonyl groups and additionally substituted by halogen and optionally by trifluoromethyl and agriculturally acceptable salts thereof are useful herbicides.
