112208-00-1 Usage
Uses
Used in Pharmaceutical Industry:
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH is used as an immunomodulatory agent for its ability to activate monocytes and macrophages, which can be beneficial in the development of treatments for various immune-related disorders and diseases.
Used in Research Applications:
In research, PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH is used as a tool compound to study the role of TLR2 (Toll-like receptor 2) in immune responses and to investigate the underlying mechanisms of monocyte and macrophage activation. This can help in understanding the complex interactions between the immune system and pathogens, as well as in the development of new therapeutic strategies.
Biological Activity
pam3csk4 is an agonist of toll-like receptor 1/2 (tlr1/2) [1].toll-like receptors (tlrs) are proteins that play an important role in the innate immune system. tlrs are mainly expressed in sentinel cells that recognize molecules derived from microbes and then activate immune cell responses.pam3csk4 is a tlr1/2 agonist. pam3csk4 increased tyrosine phosphorylation of plcγ2 and the adaptor protein lat in a syk- and src-dependent way. also, pam3csk4 evoked platelet activation [1].in a mouse rhinitis model sensitized to dermatophagoides farinae allergen, pam3csk4 significantly improved the nasal allergic symptoms and reduced total inflammation cells and the eosinophils in bronchoalveolar lavage fluid (balf). also, pam3csk4 significantly increased ifn-γ release and decreased the levels of il-13 and total ige [2]. pam3csk4 induced the production of both no and tnf-ɑ by macrophages [3]. in a murine asthma model challenged with ova, pam3csk4 significantly reduced eosinophilia and total inflammatory cell infiltrate in balf and inhibited the secretion of il-4 and il-5 induced by ova. also, pam3csk4 reduced the level of ige and increased the production of il-12 [4].
Check Digit Verification of cas no
The CAS Registry Mumber 112208-00-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,2,0 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 112208-00:
(8*1)+(7*1)+(6*2)+(5*2)+(4*0)+(3*8)+(2*0)+(1*0)=61
61 % 10 = 1
So 112208-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1
