1122091-41-1Relevant academic research and scientific papers
Preparation of optically active 1-O-alkyl-3-O-arylsulfonyl-sn-grycerol derivatives: Substrate engineering in enzyme-mediated enantioselective hydrolysis
Shimada, Yasutaka,Sato, Hiroshi,Mochizuki, Sachiyo,Matsumoto, Kazutsugu
scheme or table, p. 2981 - 2984 (2009/10/17)
Lipase PS catalyzes the enantioselective hydrolysis of various 2-acetyl compounds of the 1-O-alkyl-3-O-arylsulfonyl-sn-glycerol derivatives to afford the corresponding optically active compounds. Changing the structure of the 1-O-alkyl and 3-O-arylsulfonyl groups affects both the reactivity and enantioselectivity. Finally, the E value of the reaction for 2-acetyl-3-O-3,5-dimethylbenzenesulfonyl-1-O-4-methoxybenzyl-sn-glycerol is greater than 200. Georg Thieme Verlag Stuttgart.
