112219-43-9

Basic information

• Product Name: 4(1H)-Quinolinone, 2-methyl-6-nitro-
• CAS NO: 112219-43-9
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.185
• Mol File: 112219-43-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinolinone, 2-methyl-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinolinone, 2-methyl-6-nitro-(112219-43-9)
• EPA Substance Registry System: 4(1H)-Quinolinone, 2-methyl-6-nitro-(112219-43-9)

Safety Data

• Hazardous Substances Data: 112219-43-9(Hazardous Substances Data)

Upstream product

• 998-91-4 ethyl 3-ethoxy-2-butenoate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 1207-81-4 4-chloro-2-methyl-6-nitroquinoline 
• 99185-71-4 4-amino-2-methyl-6-nitroquinoline 
• 7511-77-5 N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide 
• 1621143-22-3 N⁴-(3-chloro-4-fluorophenyl)-2-methylquinolin-4,6-diamine 
• 1621143-23-4 N⁴-(3-bromo-4-fluorophenyl)-2-methylquinolin-4,6-diamine 
• 1621143-24-5 N⁴-(3-methylphenyl)-2-methylquinolin-4,6-diamine 
• 1621143-25-6 N⁴-(3-(trifluoromethyl)phenyl)-2-methylquinolin-4,6-diamine 
• 1621143-26-7 N⁴-(3-ethynylphenyl)-2-methylquinolin-4,6-diamine 
• 1621143-27-8 N⁴-(3-methoxyphenyl)-2-methylquinolin-4,6-diamine 
• 1621143-28-9 N⁴-(3,4,5-trimethoxyphenyl)-2-methylquinolin-4,6-diamine 
• 1621143-01-8 1-(4-(bis(2-chloroethyl)amino)phenyl)-3-(4-phenylamino-2-methylquinolin-6-yl)urea 
• 1621143-02-9 1-(4-(bis(2-chloroethyl)amino)phenyl)-3-(4-((3-fluorophenyl)amino)-2-methyl-quinolin-6-yl)urea 
• 1621143-03-0 1-(4-(bis(2-chloroethyl)amino)phenyl)-3-(4-((4-fluorophenyl)amino)-2-methyl-quinolin-6-yl)urea 
• 1621143-04-1 1-(4-(bis(2-chloroethyl)amino)phenyl)-3-(4-((3-chlorophenyl)amino)-2-methyl-quinolin-6-yl)urea 

Relevant articles and documents

Survey of solvents for the conrad-limpach synthesis of 4-hydroxyquinolones

A study of the synthesis of a 4-hydroxyquinoline derivative using the Conrad-Limpach reaction led to the identification of inexpensive and user-friendly solvents for this thermal condensation. Copyright Taylor & Francis Group, LLC.

The synthesis and biological evaluation of new DNA-directed alkylating agents, phenyl N-mustard-4-anilinoquinoline conjugates containing a urea linker

We synthesized a series of phenyl N-mustard-4-anilinoquinoline conjugates to study their antitumorigenic effects. These agents were prepared by the condensation of 4-[N,N-bis(2-chloroethyl)amino]phenyl isocyanate with 6-amino-4-methylamino or 4-anilinoquinolines. The structure-activity relationship (SAR) studies revealed that the C2-methylquinoline derivatives (18a-o) were generally more cytotoxic than the C2-phenylquinoline conjugates (23a-d) in inhibiting the cell growth of various human tumor cell lines in vitro. However, the methylamino or aniline substituents at C4 of quinoline did not influence the cytotoxic effects. The title conjugates were capable of inducing DNA cross-linking and promoting cell-cycle arrest at the G2/M phase. This study demonstrates that phenyl N-mustard-4-anilinoquinoline conjugates are generally more potent than phenyl N-mustard-4-anilinoquinazoline conjugates against the cell growth of various tumor cell-lines.