1122399-99-8Relevant academic research and scientific papers
Syntheses of (R,S)-naproxen and its 6-O-desmethylated metabolite labelled with 2H
Fontana,Venegoni
, p. 239 - 241 (2008)
Naproxen, a well-known non-steroidal anti-inflammatory drug, and its 6-O-desmethylated metabolite have been labelled with 2H. (R,S)-Naproxen 7 labelled with 2H was obtained in five steps using the commercially available [2H3]iodomethane 5 as the stable labelled reagent. The demethylation of 7 using 48% HBr in 1-butyl-3-methylimidazolium tetrafluoborate gave the corresponding 2H-labelled 6-O-desmethylated metabolite 8. Copyright
NAPTHYLENE INHIBITORS OF CYCLOOXYGENASE
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Page/Page column 38, (2010/11/18)
The present invention relates to new napthylene inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof.
