112246-50-1

Upstream product

• 18465-50-4 4,6-O-ethylidene-D-glucopyranose 
• 163959-36-2 etoposide 
• 477-47-4 (+/-)-podophyllotoxin 
• 6559-91-7 (+/-)-4'-O-demethyl-1-epipodophyllotoxin 
• 112146-43-7 Chloro-acetic acid (2S,4aS,6S,7S,8R,8aS)-7-(2-chloro-acetoxy)-6-hydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 92206-82-1 Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester 
• 149312-24-3 1-O-(trimethylsilyl)-4,6-O-ethylidene-2,3-di-O-(dichloroacetyl)-β-D-glucopyranose 
• 149312-27-6 4,6-O-ethylidene-1,2,3-tri-O-(dichloroacetyl)-α-D-glucopyranose 

Relevant academic research and scientific papers

Preparation method of etoposide, teniposide and analogs of etoposide and teniposide

The invention discloses a preparation method of etoposide, teniposide and analogs of etoposide and teniposide. The preparation method includes the following steps of 1, selective protection of 4'domethylpodophyllotoxin4'hydroxy; 2, introduction of 4 hydroxy hydroxyl; 3, removal of a protecting group. The method is mild in reaction condition and environmentally friendly, and the yield and purity of the products are high.

Syntheses of All Four Possible Diastereomers of Etoposide and Its Aminoglycosidic Analogues via Optical Resolution of (+/-)-Podophyllotoxin by Glycosidation with D- and L-Sugars

Syntheses of all four possible diastereomers of etoposide and its aminoglycosidic analogues have been achieved via optical resolution of (+/-)-podophyllotoxin by glycosidation with D- and L-sugars.