1122509-65-2Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols
Chai, Xiaoyun,Zhang, Jun,Yu, Shichong,Hu, Honggang,Zou, Yan,Zhao, Qingjie,Dan, Zhigang,Zhang, Dazhi,Wu, Qiuye
supporting information; experimental part, p. 1811 - 1814 (2009/11/30)
Based on the results of computational docking to the active site of the cytochrome P450 14α-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.
