1122593-67-2

Upstream product

• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 120-46-7 1,3-diphenylpropanedione 
• 10375-45-8 1,3-diphenyl-2-(1-phenylprop-2-ynyl)-propane-1,3-dione 
• 7338-94-5 1,3-diphenyl-2-propynone 

Relevant academic research and scientific papers

Transition-metal-catalyzed domino reactions: Efficient one-pot regiospecific synthesis of highly functionalized polysubstituted furans from electron-deficient alkynes and 2-Yn-1-ols

Based on the reactive behavior of different transition-metal catalysts, three methods for the synthesis of highly functionalized polysubstituted furan derivatives are presented: (i) copper(I) iodide catalyzed regiospecific synthesis of furan aldehydes/ketones from alkynols and diethyl but-2-ynedioate under atmospheric pressure; (ii) nano-Cu-catalyzed domino process for the regioselective synthesis of -carbonylfurans from readily accessible starting materials; (iii) silver-catalyzed one-pot cyclization in toluene at 50 C for the synthesis of furan derivatives. It was notably that all the domino reactions were smooth under mild conditions with commercially available catalysts, and afforded highly functionalized furans in moderate to good yields. As we know, furans derivatives are extremely useful organic molecules used as synthetic building blocks for the synthesis of more elaborate heterocyclic compounds. Georg Thieme Verlag Stuttgart.

Silver-catalyzed one-pot cyclization reaction of electron-DEficient alkynes and 2-Yn-1-ols: An efficient domino process to polysubstituted furans

Transition metal-catalyzed domino reactions have been used as powerful tools for the preparation of polysubstituted furans in a one-pot manner. In this paper, an efficient synthetic method was developed for the construction of tri- or tetrasubstituted furans from electron-deficient alkynes and 2-yn-1-ols by a silver-catalyzed domino reaction. It is especially noteworthy that a 2,3,5-trisubstituted 4-ynylfuran was formally obtained in an extremely direct manner without tedious stepwise synthesis. In addition, regio-isomeric furans were observed when substituted aryl alkynyl ketones were employed. This methodology represents a highly efficient synthetic route to electron-deficient furans for which catalytic approaches are scarce. The reaction proceeds efficiently under mild conditions with commercially available catalysts and materials.

Sequential gold-catalyzed reactions of 1-phenylprop-2-yn-1-ol with 1,3-dicarbonyl compounds

A variety of sequential gold-catalyzed reactions of 1-phenylprop-2-yn-1-ol with 1,3-dicarbonyl compounds are directed towards different outcomes by a suitable choice of the catalytic system, feature of 1,3-dicarbonyl and reaction conditions.

FeCl3-catalyzed propargylation-cycloisomerization tandem reaction: A facile one-pot synthesis of substituted furans

An efficient FeCl3-catalyzed tandem propargylation- cycloisomerization reaction of propargylic alcohols or acetates with 1,3-dicarbonyl compounds, leading to the synthesis of substituted furans, has been developed. Georg Thieme Verlag Stuttgart