1122649-45-9Relevant academic research and scientific papers
Design and synthesis of 3′-deoxy-3′-fluoro-2′-O-3′- C-vinylene-linked bicyclic purine nucleoside
Zhao, Baojuan,Chang, Junbiao,Wang, Qiang,Du, Yunfei,Zhao, Kang
scheme or table, p. 2993 - 2996 (2009/06/27)
Starting from D-xylose via a 3-deoxy-3α-C-ethynyl-3-fluoro sugar as a key intermediate, a novel fluorinated bicyclic purine nucleoside has been synthesized. A neighboring-group participation pathway and a mechanism involving an intramolecular cycloaddition induced by fluorine are proposed for the formation of the key intermediate and the bicyclic nucleoside, respectively. Georg Thieme Verlag Stuttgart.
