112279-72-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2,3-difluoroaniline serves as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with potential therapeutic applications. Its unique chemical structure allows for the creation of novel molecular entities that can target specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-2,3-difluoroaniline is utilized as a precursor in the production of various agrochemicals, such as pesticides and herbicides. Its reactivity and structural features enable the design of compounds that can effectively control or eliminate pests and weeds, thereby enhancing crop productivity and protection.
Used in Dye Industry:
4-Bromo-2,3-difluoroaniline is also employed in the dye industry for the synthesis of dyes with specific color properties and stability. Its incorporation into dye molecules can result in dyes with improved performance characteristics, such as resistance to fading, lightfastness, and compatibility with various substrates.
Used as an Intermediate in Organic Synthesis:
Beyond its direct applications, 4-Bromo-2,3-difluoroaniline is a valuable intermediate in the manufacturing of a wide range of organic compounds. Its unique combination of bromine and fluorine atoms allows for further chemical reactions and modifications, facilitating the synthesis of complex organic molecules for various industrial and research purposes.
Due to the potential reactivity and toxicity of 4-Bromo-2,3-difluoroaniline, it is essential to handle and store this chemical with caution to prevent any adverse effects on human health and the environment. Proper safety measures, including the use of personal protective equipment and secure storage conditions, should be implemented to ensure safe handling and minimize risks.

InChI:InChI=1/C6H4BrF2N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2

Upstream product

• 4519-40-8 2,3-difluoroanilline 

Downstream Products

• 1112969-31-9 C₁₄H₁₀BrF₂NO₂ 
• 1332331-71-1 4-[4-(1-benzofuran-5-yl)-2,3-difluorophenyl]-5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1268816-69-8 1-(2-amino-5-bromo-3,4-difluorophenyl)-2-chloroethanone 
• 1268816-71-2 1-(2-amino-5-bromo-3,4-difluorophenyl)-2-chloroethanol 
• 1312435-92-9 C₂₂H₂₀FN₃O₃S 
• 1112969-33-1 C₁₅H₁₇BrF₂N₂O₄ 
• 1112969-32-0 C₁₀H₈BrF₂NO₃ 
• 1373920-77-4 6-chloro-2,3-difluoroaniline 

Relevant academic research and scientific papers

INHIBITORS OF PROTEIN ARGININE DEIMINASES

Provided herein are inhibitors of protein arginine deiminases (PADs), pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY

Disclosed is a compound which is useful as an endothelial lipase inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is aromatic carbocycle or aromatic heterocycle,Z is —NR5—, —O— or —S—,R5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl or the like,R1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,R2 and R3 are each independently hydrogen, halogen, hydroxy or the like,R4 is a group represented by the formula: —(CR6R7)n-R8, wherein R6 and R7 are each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, R8 is carboxy, cyano, substituted or unsubstituted alkyl or the like, Rx is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,m is an integer of 0 to 3.

SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES

The present application provides novel substituted quinazoline and pyrido- pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

Methods and Processes For Syntheses and Manufacture of Antimicrobial 1(Ortho-Fluorophenyl)dihydropyridones

Provided herein are methods and processes for synthesis and manufacture of compounds of formula I: or its crystal forms, pharmaceutical acceptable salts, prodrugs, hydrates, or solvates thereof.

Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections

The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF

The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof as a multiplex inhibitor, a method for the preparation thereof, and a pharmaceutical composition and a therapeutic composition comprising same as an active ingredient. The inventive quinazoline derivative as a multiplex inhibitor can selectively and effectively inhibit diseases caused by the overactivity of a tyrosine kinase.