112283-18-8Relevant academic research and scientific papers
hTERT MODULATORS AND METHODS OF USE
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Paragraph 0093; 0094; 0096; 0115, (2018/02/28)
The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
Benzoylphenylurea sulfur analogues with potent antitumor activity
Hallur, Gurulingappa,Jimeno, Antonio,Dalrymple, Susan,Zhu, Tao,Jung, M. Katherine,Hidalgo, Manuel,Isaacs, John T.,Sukumar, Saraswati,Hamel, Ernest,Khan, Saeed R.
, p. 2357 - 2360 (2007/10/03)
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was
