1123-09-7

Basic information

• Product Name: 3,5-Dimethyl-2-cyclohexen-1-one
• Synonyms: 3,5-DIMETHYL-2-CYCLOHEXEN-1-ONE;3,5-Dimethyl-2-cyclohexene-1-one;3,5-dimethylcyclohex-2-en-1-one;3,5-Dimethyl-2-cyclohexen-1-on;3,5-Dimethyl-2-cyclohexen-1-one,99%;3,5-diMethylcyclohex-2-enone
• CAS NO: 1123-09-7
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.18
• EINECS: 214-369-2
• Product Categories: C7 to C8;Carbonyl Compounds;Ketones;Building Blocks;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 1123-09-7.mol
• Article Data: 19

Chemical Properties

• Melting Point: 166 °C(Solv: ethanol (64-17-5))
• Boiling Point: 211-212 °C(lit.)
• Flash Point: 175 °F
• Appearance: /
• Density: 0.881 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.213mmHg at 25°C
• Refractive Index: n20/D 1.483(lit.)
• CAS DataBase Reference: 3,5-Dimethyl-2-cyclohexen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethyl-2-cyclohexen-1-one(1123-09-7)
• EPA Substance Registry System: 3,5-Dimethyl-2-cyclohexen-1-one(1123-09-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36-20/21/22
• Safety Statements: 36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 1123-09-7(Hazardous Substances Data)

Usage

Uses

3,5-Dimethyl-2-cyclohexen-1-one can be used as a starting material for the synthesis of the intermediate 3,5-dimethyl-2-cyclohexen-1-one.

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 1664, 1977 DOI: 10.1021/jo00429a048

InChI:InChI=1/C8H12O/c1-6-3-7(2)5-8(9)4-6/h4,7H,3,5H2,1-2H3/t7-/m1/s1

Upstream product

• 108-75-8 2,4,6-trimethyl-pyridine 
• 5526-47-6 4-methyl-heptane-2,6-dione 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 6102-15-4 2,6-dimethyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester 
• 81930-38-3 2-acetyl-5-methyl-1,3-cyclohexanedione 
• 141-97-9 ethyl acetoacetate 
• 107-93-7 (E)-but-2-enoic acid 
• 541-47-9 3-Methylbutenoic acid 
• 144890-14-2 (4-Methyl-2,6-dioxo-heptyl)-phosphonic acid diethyl ester 
• 185035-84-1 7,9-Dimethyl-1,4-dioxa-spiro[4.5]dec-6-ene 
• 110-89-4 piperidine 
• 75-07-0 acetaldehyde 
• 7647-01-0 hydrogenchloride 
• 27760-59-4 3,5-dibenzoyl-2,4,6-trimethyl-1,4-dihydro-pyridine 

Downstream Products

• 861539-13-1 1-ethyl-3,5-dimethyl-cyclohex-2-enol 
• 33843-55-9 1,3,5-trimethyl-cyclohex-2-enol 
• 1731-26-6 1,3,5-trimethyl-2,4-cyclohexadiene 
• 57196-86-8 1,5-dimethyl-3-methylene-1-cyclohexene 
• 697-82-5 2,3,5-trimethylphenol 
• 7143-12-6 1,3-dimethyl-5-oxo-cyclohexanecarbonitrile 
• 79151-35-2 3-ethyl-2-(3,5-dimethyl-cyclohex-2-enylidenemethyl)-benzothiazolium; iodide 
• 60221-07-0 3-isopropylidene-1,5-dimethyl-cyclohexene 
• 73650-03-0 3,5-dimethylcyclohexanamine 
• 861551-25-9 3,5-dimethyl-1-phenyl-cyclohex-2-enol 
• 76257-68-6 1,5-dimethyl-3-phenyl-cyclohexa-1,3-diene 
• 108-75-8 2,4,6-trimethyl-pyridine 
• 638-04-0 1,3-dimethylcyclohexane 
• 2320-30-1 3,5-dimethylcyclohexanone 

Relevant articles and documents

Eu(fod)3-catalyzed rearrangement of allylic methoxyacetates

-

Preparation method of cis, cis-3, 5-dimethyl-1-cyclohexanol

The invention belongs to the field of chemistry, and discloses a synthesis method of a cis, cis-3, 5-dimethyl-1-cyclohexanol compound shown as a formula (I). Acetaldehyde and ethyl acetoacetate are used as raw materials, and cis, cis-3, 5-dimethyl-1-cyclohexanol is synthesized by a series of reactions such as knoevenagel condensation, hydrolysis, decarboxylation, hydrogenation reduction, reduction, acylating chlorination, hydrolysis and the like. The raw materials and auxiliary materials of the route are simple and easily available, the reaction conditions are mild, the operation is simple andconvenient, the synthesis cost is low, and the obtained product has high chiral purity (the product/isomer ratio is 30: 1-100: 1) and is suitable for large-scale production.

Access to Functionalized Quaternary Stereocenters via the Copper-Catalyzed Conjugate Addition of Monoorganozinc Bromide Reagents Enabled by N, N-Dimethylacetamide

Monoorganozinc reagents, readily obtained from alkyl bromides, display excellent reactivity with β,β-disubstituted enones and TMSCl in the presence of Cu(I) and Cu(II) salts to synthesize a variety of cyclic functionalized β-quaternary ketones in 38-99% yields and 9:1-20:1 diastereoselectivities. The conjugate addition features a pronounced improvement in DMA using monoorganozinc bromide reagents. A simple one-pot protocol that harnesses in situ generated monoorganozinc reagents delivers comparable product yields.