1123-73-5Relevant academic research and scientific papers
Synthesis of Highly Substituted Phenols and Benzenes with Complete Regiochemical Control
Zhang, Xiaojie,Beaudry, Christopher M.
supporting information, p. 6086 - 6090 (2020/08/12)
Substituted phenols are requisite molecules for human health, agriculture, and diverse synthetic materials. We report a chemical synthesis of phenols, including penta-substituted phenols, that accommodates programmable substitution at any position. This method uses a one-step conversion of readily available hydroxypyrone and nitroalkene starting materials to give phenols with complete regiochemical control and in high chemical yield. Additionally, the phenols can be converted into highly and even fully substituted benzenes.
Synthesis of aromatic compounds using combinations of ring-closing olefin metathesis, dehydration, oxidation, and tautomerization
Yoshida, Kazuhiro,Toyoshima, Takeharu,Imamoto, Tsuneo
scheme or table, p. 1512 - 1517 (2009/05/06)
An approach to aromatic compounds using combinations of ring-closing olefin metathesis (RCM), dehydration, oxidation, and tautomerization is reported. The RCM reaction of l,7-diene-3,5-diols, which were readily prepared by the allylation of aldol products, gave corresponding cyclized products, 4-cyclohexene-l,3-diols, in high yields. The subsequent dehydration or oxidation of 4-cyclohexene-1,3-diols led to versatile substituted benzenes including phenol and resorcinol derivatives.
Efficient synthetic routes to aromatic compounds using ring-closing olefin metathesis followed by dehydration, oxidation, and tautomerization
Yoshida, Kazuhiro,Toyoshima, Takeharu,Imamoto, Tsuneo
, p. 3774 - 3776 (2008/03/12)
A simple synthetic approach to aromatic compounds using combinations of RCM, dehydration, oxidation, and tautomerization is described. The Royal Society of Chemistry.
