112320-51-1Relevant articles and documents
Intramolecular Nucleophilic Catalysis by the Neighboring Hydroxyl Group in Acid- and Base-Catalyzed Hydrolysis of Aromatic Sulfonamides and Sultones. Mechanism of Intramolecular Nucleophilic Substitution at Sulfonyl Sulfur
Wagenaar,Anno,Engberts, Jan B.F.N.
, p. 768 - 772 (2007/10/02)
This paper reports kinetic data illustrating the effectiveness of the Thorpe-Ingold gem-dialkyl effect in speeding the intramolecular nucleophilic catalyzed conversion of o-(1-hydroxyalkyl)-N,N-dimethylbenzenesulfonamides 1 into the corresponding sultones