1123231-07-1Relevant articles and documents
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A wingless β-catenin agonist that increases bone formation rate
Pelletier, Jeffrey C.,Lundquist IV, Joseph T.,Gilbert, Adam M.,Alon, Nipa,Bex, Frederick J.,Bhat, Bheem M.,Bursavich, Mattew G.,Coleburn, Valerie E.,Felix, Luciana A.,Green, Daniel M.,Green, Paula,Hauze, Diane B.,Kharode, Yogendra P.,Lam, Ho-Sun,Lockhead, Susan R.,Magolda, Ronald L.,Matteo, Jeanne J.,Mehlmann, John F.,Milligan, Colleen,Murrills, Richard J.,Pirrello, Jennifer,Selim, Sally,Sharp, Michael C.,Unwalla, Ray J.,Vera, Matthew D.,Wrobel, Jay E.,Yaworsky, Paul,Bodine, Peter V. N.
supporting information; experimental part, p. 6962 - 6965 (2010/08/03)
A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt β-catenin cellular messaging system. Hit-tolead in