112356-54-4

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InChI:InChI=1/C16H17NO4/c1-21-12-7-5-11(6-8-12)9-10-17-16(20)15-13(18)3-2-4-14(15)19/h2-8,18-19H,9-10H2,1H3,(H,17,20)

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Blood matrix effects for male and female Wistar rats, in simultaneous HPLC-UV determination of riparin (cas 112356-54-4) I and III from Aniba riparia (Nees) Mez. (Lauraceae)07/28/2019

Aniba riparia (Nees) Mez. (Lauraceae) is popularly known as “louro”, and is found in Amazonia and in the Guianas, its distribution extends to the Andes. Alkamide alkaloids were isolated from its green fruit; they were denominated riparin I (methyl ether of N-benzoyl tyramine), riparin II (meth...detailed

Evaluation of the anti-inflammatory activity of riparin (cas 112356-54-4) II (O-methil-N-2-hidroxi-benzoyl tyramine) in animal models07/27/2019

Riparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the in...detailed

riparin (cas 112356-54-4) II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms07/26/2019

Riparin II (RIP II) is an alkamide isolated from Aniba riparia that has presented antidepressant and anxiolytic effects in acute stress behavioral models. This study aimed to investigate the activity of RIP II in a corticosterone-induced depression mice model. Corticosterone (20 mg/kg, s.c.) was...detailed

riparin (cas 112356-54-4) A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration07/25/2019

Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the a...detailed

Antinociceptive activity of riparin (cas 112356-54-4) II from Aniba riparia: Further elucidation of the possible mechanisms07/24/2019

Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using cl...detailed

Pathophysiological investigations, anxiolytic effects and interaction of a semisynthetic riparin (cas 112356-54-4) with benzodiazepine receptors07/23/2019

We have reported Riparin A as a promising antiparasitic molecule ​​against Leishmania amazonensis promastigotes. This work evaluated the acute oral toxicity of Riparin A and its anxiolytic effects using in vivo models and computational tools. Mice were submitted to acute oral toxicity tests (Gui...detailed

Synthesis, characterization and cytotoxic evaluation of inclusion complexes between riparin (cas 112356-54-4) A and β-cyclodextrin07/22/2019

This study performed a physicochemical characterization of the inclusion complex generated between Riparin A and β-cyclodextrin (Rip A/β-CD) and compared the cytotoxic potential of the incorporated Rip A upon Artemia salina larvae. Samples were analyzed by phase solubility diagram, dissolution...detailed

Antiparasitic, structural, pharmacokinetic, and toxicological properties of riparin (cas 112356-54-4) derivatives07/21/2019

Schistosomiasis, caused by helminth flatworms of the genus Schistosoma, is one of the most important parasitic diseases in the world, affecting over 200 million people in developing countries. Riparins are natural alkamides found in Aniba riparia (Lauraceae) fruits that possess several pharmacol...detailed

Reversal effect of riparin (cas 112356-54-4) IV in depression and anxiety caused by corticosterone chronic administration in mice07/19/2019

Mental disorders have a multifactorial etiology and stress presents as one of the causal factors. In depression, it is suggested that high cortisol concentration contributes directly to the pathology of this disease. Based on that, the study aims to evaluate the potential antidepressant effect o...detailed