112358-75-5

Upstream product

• 107-21-1 ethylene glycol 
• 94-66-6 2-allylcyclohexan-1-one 
• 93743-29-4 trans-2-(prop-2-enyl)cyclohexanecarboxaldehyde 
• 129143-85-7 3-(2-methoxymethylenecyclohexyl)prop-1-ene 

Downstream Products

• 112358-79-9 (E)-ethyl 5-(2-formylcyclohexyl)-2-(trimethylsilylmethyl)pent-2-enoate 
• 112358-78-8 (Z)-ethyl 5-<2-(ethylenedioxymethyl)cyclohexyl>-2-(trimethylsilylmethyl)pent-2-enoate 
• 112358-78-8 (E)-ethyl 5-<2-(ethylenedioxymethyl)cyclohexyl>-2-(trimethylsilylmethyl)pent-2-enoate 
• 112358-79-9 (Z)-ethyl 5-(2-formylcyclohexyl)-2-(trimethylsilylmethyl)pent-2-enoate 
• 112358-77-7 3-propanal 

Relevant academic research and scientific papers

A synthetic approach to 5/5/6-polycyclic tetramate macrolactams of the discodermide type

A flexible synthetic route to the 16-membered tetramate-embedding macrocyclic scaffold present in various polycyclic tetramate macrolactams (PTMs) was developed which differs from the seminal synthesis of ikarugamycin by Boeckman Jr. in protecting groups and the order of connections. We also devised a short approach to various stereoisomers of the 5/5/6-tricarbocyclic motif found in discodermide and other PTMs, starting from the Weiss’ diketone.

A Short-step Synthesis of 14,15-Dinoreudesmanolides using Intramolecular Cyclization of an Allylsilane

14,15-Dinoreudesman-12,6-olides, α-methylene-γ-lactones fused to a trans-decalin ring with all three possible stereochemistries, were synthesized from a simple dialdehyde monoacetal via intramolecular cyclization of ethyl 5-(2-formylcyclohexyl)-2-(trimeth

A Simple Synthesis of cis- and trans-Fused 14,15-Dinoreudesmanolides

Three possible stereoisomers of 14,15-dinoreudesmanolide, the structure of which consists of an α-methylene-γ-lactone ring fused to a trans-decalin ring, have been synthesized from a dialdehyde monoacetal via α-trimethylsilymethyl-α,β-unsaturated esters.