1123582-44-4Relevant academic research and scientific papers
New class of algicidal compounds and fungicidal activities derived from a chromene amide of amyris texana
Meepagala, Kumudini M.,Schrader, Kevin K.,Burandt, Charles L.,Wedge, David E.,Duke, Stephen O.
experimental part, p. 9476 - 9482 (2011/05/14)
A chromene amide, N-[2-(2,2-dimethyl-2H-1-benzopyran-6-yl)ethyl]-N,3- dimethylbutanamide, was isolated from the EtOAc extract of the leaves of Amyris texana and found to have moderate antifungal activity against Colletotrichum spp. and selective algicidal activity against Planktothrix perornata, a cyanobacterium (blue-green alga) that causes musty off-flavor in farm-raised channel catfish (Ictalurus punctatus). To improve the selective algicidal activity and provide water solubility, a series of chromene analogues were synthesized and evaluated for algicidal activity using a 96-well microplate rapid bioassay. In addition, the chromene analogues were evaluated for antifungal and phytotoxic activities. Hydrochloride salts of a chromene amine analogue showed improved water solubility and selectivity toward P. perornata with activity comparable to that of the naturally occurring chromene amide.
HETEROCYCLIC COMPOUND AND USE THEREOF
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Page/Page column 102-103, (2010/06/11)
Disclosed is a heterocyclic compound having a strong Raf inhibitory activity. Specifically disclosed is a compound represented by the formula (I), (II) or (III) below, or a salt thereof. (In the formulae, the symbols are as defined in the description.)
