112361-54-3Relevant academic research and scientific papers
1,2,4-triazinone derivatives, their preparation and use
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, (2008/06/13)
Compounds of formula (I): STR1 (in which: R1 is hydrogen or alkl; R2 is a variety of groups or atoms; R3 is optionally substituted hydroxy or --(NH)n --NR5 R6, wherein R5 and R6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C1 -C6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR1 --NH--COOR7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R3 in any order.
