112369-45-6Relevant academic research and scientific papers
Studies on log Po/w of quinoxaline di-N-oxides: A comparison of RP-HPLC experimental and predictive approaches
Moreno, Elsa,Gabano, Elisabetta,Torres, Enrique,Platts, James A.,Ravera, Mauro,Aldana, Ignacio,Monge, Antonio,Perez-Silanes, Silvia
scheme or table, p. 7893 - 7908 (2011/11/05)
As reported in our previous papers, a series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and studied as anti-tuberculosis agents. Here, the capability of the shake-flask method was studied and the retention time (expressed as log K) of 20 compounds were determined by RP-HPLC analysis. We found that the prediction of log P by the RP-HPLC analysis can result in a high accuracy and can replace the shake-flask method avoiding the experimental problems presented by quinoxaline di-N-oxides. The studied compounds were subjected to the ALOGPS module with the aim of comparing experimental log Po/w values and predicted data. Moreover, a preliminary in silico screening of the QSAR relationship was made confirming the influence of reduction peak potential, lipophilicity, H-bond donor capacity and molecular dimension descriptors on anti-tuberculosis activity.
New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents
Ancizu, Saioa,Moreno, Elsa,Solano, Beatriz,Villar, Raquel,Burguete, Asunción,Torres, Enrique,Pérez-Silanes, Silvia,Aldana, Ignacio,Monge, Antonio
experimental part, p. 2713 - 2719 (2010/06/14)
Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).
SYNTHESIS AND SPECTROSCOPIC STUDIES ON SOME NEW SUBSTITUTED 2-QUINOXALINECARBOXAMIDES AND THEIR N-OXIDES
Sabri, Salim S.,El-Abadelah, Mustafa M.,Al-Bitar, Bassam A.
, p. 699 - 711 (2007/10/02)
Series of new 2-(N-phenylcarbamoyl)-3-methylquinoxaline 1,4-dioxides (I), monoxides (II,III) and their non-oxygenated analogues (IV), as well as the corresponding series lacking the C3-methyl (V-VIII) have been prepared, and their 1H-nmr spectr
