112371-43-4Relevant academic research and scientific papers
Nucleophilic Attack on a Carbonyl Group Conjugated to a Chiral Centre: A Search For a Vinylogous Cram's Rule
Fleming, Ian,Kuehne, Hardy,Takai, Ken
, p. 725 - 728 (2007/10/02)
In a search for a vinylogous version of Cram's rule, 1,4-diphenylbut-2-ene-1,4-dione (5), 4-methoxy-1,4-diphenylbut-2-en-1-one (9), and hex-3-ene-2,5-dione (13) are found to be reduced with low or negligible diastereoselectivity.Similarly, the phenyl Grignard reagent showed no diastereoselectivity in its reaction with 4-methoxy-4-phenylbut-2-enal (12)
