1123786-69-5

Basic information

• Product Name: (S)-(tetrahydro-2H-pyran-3-yl)methanol
• Synonyms: (S)-(tetrahydro-2H-pyran-3-yl)methanol;(3S)-Tetrahydro-2H-pyran-3-ylmethanol;(3S)-OXAN-3-YLMETHANOL
• CAS NO: 1123786-69-5
• Molecular Formula: C6H12O2
• Molecular Weight: 116.15828
• Mol File: 1123786-69-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 214.3±8.0 °C(Predicted)
• Appearance: /
• Density: 1.000±0.06 g/cm3(Predicted)
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: (S)-(tetrahydro-2H-pyran-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(tetrahydro-2H-pyran-3-yl)methanol(1123786-69-5)
• EPA Substance Registry System: (S)-(tetrahydro-2H-pyran-3-yl)methanol(1123786-69-5)

Safety Data

• Hazardous Substances Data: 1123786-69-5(Hazardous Substances Data)

Usage

General Description

(S)-(tetrahydro-2H-pyran-3-yl)methanol, also known as THP-3-methanol, is an organic compound with the molecular formula C6H12O2. It is a colorless liquid with a sweet, fruity odor and is commonly used as a flavoring agent in the food industry. THP-3-methanol is a chiral compound, meaning it has two enantiomers, designated as (R) and (S). The (S)-enantiomer is the naturally occurring form of the compound and is commonly found in nature. It is often used in synthetic organic chemistry as a chiral building block for the synthesis of various pharmaceuticals and bioactive compounds. THP-3-methanol is also used in the production of fragrances and perfumes due to its pleasant odor.

Upstream product

• 251922-47-1 3-(oxetan-3-yl)propan-1-ol 

Relevant articles and documents

A broadly applicable and practical oligomeric (salen)Co catalyst for enantioselective epoxide ring-opening reactions

The (salen)Co catalyst (4a) can be prepared as a mixture of cyclic oligomers in a short, chromatography-free synthesis from inexpensive, commercially available precursors. This catalyst displays remarkable enhancements in reactivity and enantioselectivity relative to monomeric and other multimeric (salen)Co catalysts in a wide variety of enantioselective epoxide ring-opening reactions. The application of catalyst 4a is illustrated in the kinetic resolution of terminal epoxides by nucleophilic ring-opening with water, phenols, and primary alcohols; the desymmetrization of meso epoxides by addition of water and carbamates; and the desymmetrization of oxetanes by intramolecular ring opening with alcohols and phenols. The favorable solubility properties of complex 4a under the catalytic conditions facilitated mechanistic studies, allowing elucidation of the basis for the beneficial effect of oligomerization. Finally, a catalyst selection guide is provided to delineate the specific advantages of oligomeric catalyst 4a relative to (salen)Co monomer 1 for each reaction class.