1123799-98-3Relevant academic research and scientific papers
Synthesis and anti-HIV activity of new 6-thioarylpyrimidines and related compounds
Al-Masoudi, Iman A.,Al-Soud, Yaseen A.,Al-Masoudi, Najim A.,Noori, Saman H.,Schuppler, Thilo
, p. 1571 - 1583 (2008)
A series of new 5-nitro- and 5-amino-6-arylsulfanyl-1-propyl-1H-pyrimidin- 2,4-diones (4-9) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). Similarly, 6-arylsulfanyl-1,3- dimethyl-5-nitro-1H-pyrimidin-2,4-diones (12-15) were prepared from 10. A new 2-amino-2-phenyl-7-phenylsulfanyl-imidazo[1,2-a]pyrimidin-5-one (18) has been synthesized from reaction of 17 with α-bromoacetophenone in the presence of NaH. The newly synthesized compounds were evaluated for their anti HIV-1 and HIV-2 activity in MT-4 cells. Copyright Taylor & Francis Group, LLC.
