112383-14-9

Upstream product

• 112383-12-7 1-tert-butoxycarbonyl-2-propylidenehydrazine 
• 870-46-2 t-butoxycarbonylhydrazine 
• 112383-13-8 N'-propylhydrazinecarboxylic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 112382-89-5 N-<(1R)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-valyl-L-prolyl-α-azanorvaline benzyl ester 
• 112383-19-4 Val-Pro-Aznva-OCH₂Ph*HCl 
• 112382-84-0 N-<(1S)-(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-valyl-L-prolyl-α-azanorvaline benzyl ester 
• 112383-35-4 Leu-Ψ(CH2S)-Ala-Aznva-OCH2Ph hydrochloride 
• 112383-25-2 prolyl-α-azanorvaline benzyl ester hydrochloride 
• 112383-10-5 N-<(1S)-(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-leucyl-Ψ(CH2S)-L-alanyl-α-azanorvaline benzyl ester 
• 112383-16-1 N-t-butoxycarbonyl-L-valyl-L-prolyl-α-azanorvaline benzyl ester 
• 112382-95-3 N-<1(S)-(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-prolyl-α-azanorvaline benzyl ester 
• 112382-96-4 N-<1(S)-(1-methoxycarbonyl-2-methylpropyl)carbamoyl>-L-prolyl-α-azanorvaline benzyl ester 
• 112383-34-3 N-t-butoxycarbonyl-L-leucyl-Ψ(CH2S)-L-alanyl-α-azanorvaline benzyl ester 
• 112383-24-1 N-t-butoxycarbonyl-L-prolyl-α-azanorvaline benzyl ester 
• 112383-15-0 α-azanorvaline benzyl ester hydrochloride 

Relevant academic research and scientific papers

Novel azapeptide inhibitors of hepatitis C virus serine protease

Azapeptides are known inhibitors of several serine and cysteine proteases. In seeking different classes of inhibitors for the HCV serine protease, a series of novel azapeptide-based inhibitors were investigated which incorporated noncleavable P1/P1′ aza-a

INHIBITORS OF HUMAN LEUCOCYTE ELASTASE. PEPTIDES INCORPORATING AN &α-AZANORVALINE RESIDUE OR A THIOMETHYLENE LINKAGE IN PLACE OF A PEPTIDE BOND

Peptides containing an α-azanorvaline residue at the C-terminus and N- group at the N-terminus have been made as inhibitors of human leucocyte elastase.A number of analogues with an amide bond replaced by a thiomethylene group have also been prepared.The analogues were tested against leucocyte elastase using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as a substrate and the results were obtained as IC50 values.Both types of analogues inhibited the leucocyte elastase; the most potent of these was N--L-valyl-L-prolyl-α-azanorvaline phenyl ester ( 2 ) ( IC50 0.28 μM, Ki 0.02 μM ).