1123837-28-4

Basic information

• Product Name: tert-butyl [(6-bromopyridin-3-yl)methyl](2-methoxyethyl)carbamate
• Synonyms: tert-butyl [(6-bromopyridin-3-yl)methyl](2-methoxyethyl)carbamate
• CAS NO: 1123837-28-4
• Molecular Weight: 345.236
• Mol File: 1123837-28-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: tert-butyl [(6-bromopyridin-3-yl)methyl](2-methoxyethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [(6-bromopyridin-3-yl)methyl](2-methoxyethyl)carbamate(1123837-28-4)
• EPA Substance Registry System: tert-butyl [(6-bromopyridin-3-yl)methyl](2-methoxyethyl)carbamate(1123837-28-4)

Safety Data

• Hazardous Substances Data: 1123837-28-4(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 149806-06-4 6-bromonicotinaldehyde 
• 1123837-99-9 N-((6-bromopyridin-3-yl)methyl)-2-methoxyethan-1-amine 

Downstream Products

• 1123838-02-7 tert-butyl {[6-(7-chlorothieno[3,2-b]pyridin-2-yl)pyridin-3-yl]methyl}(2-methoxyethyl)carbamate 
• 1123837-31-9 tert-butyl {[6-[7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl]pyridin-3-yl]methyl}(2-methoxyethyl)carbamate 
• 1187214-06-7 C₃₇H₃₈FN₅O₈S₂ 
• 1187213-92-8 tert-butyl (6-(7-(4-(3-(3-(dimethylphosphoryl)phenyl)ureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate 
• 1187212-81-2 N₁-(3-fluoro-4-(2-(5-((N-(2-methoxyethyl)acetamido)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N₃-(3-(methylsulfonyl)phenyl)malonamide 
• 1187212-80-1 N₁-(3-fluoro-4-(2-(5-((2-methoxyethylammo)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N₃-(3-(methylsulfonyl)phenyl)malonamide 
• 1187214-23-8 tert-butyl (6-(7-(4-(3-(cyclopropylsulfonyl)ureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate 
• 1187214-21-6 4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl 2,2,2-trifluoroethyl methylcarbamate 
• 1187212-61-8 1-(3-(dimethylphosphoryl)phenyl)-3-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea 
• 1187214-02-3 tert-butyl (6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate 
• 1187214-05-6 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoic acid 
• 1187214-04-5 methyl 3-(4-(2-(5-((tert-butoxycarbonyl(2-methoxyemyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-3-oxopropanoate 
• 1187212-94-7 N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamoyl)cyclopropanesulfonamide 
• 1187214-01-2 tert-butyl (6-(7-(4-(cyclopropanecarboxamido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate 

Relevant articles and documents

CRYSTALLINE FORM OF A MULTI-TYROSINE KINASE INHIBITOR, METHOD OF PREPARATION, AND USE THEREOF

The present invention relates to crystalline forms of N-(3 -fluoro-4-((2-(5-(((2- methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4- fluorophenyl)cyclopropane- 1,1 -di carboxamide (Compound 1), pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore.

TREATMENT OF CANCER WITH ANTI-OX40 ANTIBODIES AND MULTI-KINASE INHIBITORS

The present disclosure provides methods of treating cancer with non-competitive, agonist anti-OX40 antibodies and antigen-binding fragments thereof that bind to human OX40 (ACT35, CD134, or TNFRSF4), in combination with a multi-kinase inhibitor.

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Since a thienopyridine derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof of the present invention has an excellent effect of inhibiting protein kinase activity, a pharmaceutical composition comprising the same can be usefully used for preventing or treating diseases related to protein kinase activity.COPYRIGHT KIPO 2020